Largest nonprofits in South Carolina by revenue
| # | Nonprofit | City | Focus area | Revenue |
|---|---|---|---|---|
| 1 | Advanced Technology International | Summerville | Science & Technology | $4.9 billion |
| 2 | Prisma Health - Upstate | Greenville | Health Care | $3.6 billion |
| 3 | Prisma Health-Midlands | Greenville | Health Care | $2.1 billion |
| 4 | Lexington Health Inc | West Columbia | Health Care | $1.8 billion |
| 5 | McLeod Regional Medical Center Of The Pee Dee Inc | Florence | Health Care | $1.5 billion |
| 6 | Prisma Health-University Medical Group | Greenville | Health Care | $925.8 million |
| 7 | Anmed Health | Anderson | Health Care | $854.6 million |
| 8 | St Francis Hospital Inc | Greenville | Not listed | $850.9 million |
| 9 | Bon Secours-St Francis Xavier Hospital Inc | Charleston | Health Care | $620.6 million |
| 10 | The Blackbaud Giving Fund | Daniel Island | Philanthropy, Voluntarism & Grantmaking Foundations | $545.8 million |
| 11 | Roper Hospital Inc | Charleston | Health Care | $539.5 million |
| 12 | Apella Health Management Inc | Spartanburg | Philanthropy, Voluntarism & Grantmaking Foundations | $524.7 million |
| 13 | McLeod Loris Seacoast Hospital | Florence | Health Care | $466.9 million |
| 14 | Conway Hospital Inc | Conway | Health Care | $416.5 million |
| 15 | Prisma Health Medical Group-Midlands | Greenville | Education | $401.1 million |
| 16 | McLeod Health | Florence | Health Care | $399.6 million |
| 17 | Prisma Health | Greenville | Health Care | $339.5 million |
| 18 | Charter Institute At Erskine | Columbia | Education | $299.9 million |
| 19 | Furman University | Greenville | Education | $296.9 million |
| 20 | Georgetown Memorial Hospital | Georgetown | Health Care | $268.1 million |
| 21 | Georgetown Hospital System | Georgetown | Health Care | $265.8 million |
| 22 | Roper St Francis Healthcare | Ladson | Health Care | $259.4 million |
| 23 | Prisma Health - Blount Memorial Hospital Inc | Greenville | Health Care | $240.5 million |
| 24 | Greenville Health Corporation | Greenville | Health Care | $230.3 million |
| 25 | Waccamaw Community Hospital | Georgetown | Health Care | $225.7 million |
The full list includes all 1,252 South Carolina nonprofits with $1M+ revenue, with street address, ZIP, EIN, assets, income and tax period, plus every other state.
South Carolina cities with the most $1M+ nonprofits
- Columbia: 177
- Greenville: 149
- Charleston: 112
- Spartanburg: 67
- N Charleston: 37
- Greenwood: 35
- Rock Hill: 34
- Florence: 33
- Anderson: 26
- Mt Pleasant: 24
Most common focus areas
- Education: 287
- Human Services: 159
- Health Care: 112
- Arts, Culture & Humanities: 57
- Community Improvement & Capacity Building: 53
- Philanthropy, Voluntarism & Grantmaking Foundations: 46
- Housing & Shelter: 42
- Religion-Related: 40
Where does this data come from?
The IRS Exempt Organizations Business Master File, downloaded in October 2026. Figures are as reported on each organization's latest return on file with the IRS. Personal contact names are not included.