Largest nonprofits in Missouri by revenue
| # | Nonprofit | City | Focus area | Revenue |
|---|---|---|---|---|
| 1 | Bjc Health System | Saint Louis | Health Care | $11.3 billion |
| 2 | Washington University | St Louis | Education | $5.9 billion |
| 3 | Ascension Seton | Saint Louis | Not listed | $3.3 billion |
| 4 | Ascension Health Alliance | Saint Louis | Not listed | $3.3 billion |
| 5 | Childrens Mercy Hospital | Kansas City | Health Care | $2.3 billion |
| 6 | Ssm Health Care St Louis | Saint Louis | Health Care | $2.2 billion |
| 7 | Bjc Health System | Saint Louis | Health Care | $2.0 billion |
| 8 | Mercy Hospitals East Communities | Chesterfield | Health Care | $2.0 billion |
| 9 | Lester E Cox Medical Center | Springfield | Health Care | $2.0 billion |
| 10 | Sacred Heart Health System Inc | Saint Louis | Health Care | $1.8 billion |
| 11 | Mhm Support Services | Chesterfield | Not listed | $1.7 billion |
| 12 | St Vincent Hospital & Health Care | Saint Louis | Health Care | $1.7 billion |
| 13 | Mercy Hospital Springfield | Springfield | Health Care | $1.5 billion |
| 14 | Ssm Health Care Corporation | Saint Louis | Health Care | $1.4 billion |
| 15 | Saint Thomas West Hospital | Saint Louis | Health Care | $1.3 billion |
| 16 | St Louis University | Saint Louis | Education | $1.2 billion |
| 17 | Ssm Health Care Of Oklahoma Inc | Saint Louis | Health Care | $1.1 billion |
| 18 | Ascension Health-Is Inc | Saint Louis | Not listed | $989.7 million |
| 19 | Ssm-Sluh Inc | Saint Louis | Not listed | $947.9 million |
| 20 | Truman Medical Center Incorporated | Kansas City | Health Care | $892.0 million |
| 21 | Heartland Regional Medical Center | Saint Joseph | Health Care | $883.4 million |
| 22 | Ascension Via Christi Hospitals Wichita Inc | Saint Louis | Health Care | $844.6 million |
| 23 | Mercy Clinic East Communities | Chesterfield | Unknown | $804.6 million |
| 24 | Greater Kansas City Community Foundation | Kansas City | Philanthropy, Voluntarism & Grantmaking Foundations | $781.8 million |
| 25 | Ssm Health Care Of Wisconsin Inc | Saint Louis | Health Care | $770.2 million |
The full list includes all 1,997 Missouri nonprofits with $1M+ revenue, with street address, ZIP, EIN, assets, income and tax period, plus every other state.
Missouri cities with the most $1M+ nonprofits
- Saint Louis: 617
- Kansas City: 354
- Springfield: 108
- Columbia: 79
- Joplin: 39
- St Louis: 38
- Chesterfield: 38
- Jefferson Cty: 37
- Saint Joseph: 27
- Cpe Girardeau: 24
Most common focus areas
- Human Services: 346
- Health Care: 292
- Education: 236
- Arts, Culture & Humanities: 86
- Philanthropy, Voluntarism & Grantmaking Foundations: 73
- Community Improvement & Capacity Building: 58
- Housing & Shelter: 56
- Employment: 54
Where does this data come from?
The IRS Exempt Organizations Business Master File, downloaded in October 2026. Figures are as reported on each organization's latest return on file with the IRS. Personal contact names are not included.